Results
| PMID | 24945100 |
| Gene Name | PGR |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 38 |
| Population details | 38 women with peritoneal endometriosis diagnosed during investigation for secondary infertility |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | ERA, PR, PR-B, CRYAB |
| Other associated phenotypes |
Endometriosis |
|
Hum Fertil (Camb). 2015 Mar;18(1):30-7. doi: 10.3109/14647273.2014.922705. Epub Moberg, Christian| Bourlev, Vladimir| Ilyasova, Natalia| Olovsson, Matts Department of Women's and Children's Health, Uppsala University , Uppsala , Sweden. Endometriosis affects fertility in many women and may partly be due to decreased endometrial receptivity. Several mechanisms have been suggested, notably, progesterone resistance for which a number of candidate biomarkers have been suggested. Here we demonstrate aberrant levels of steroid hormone receptors and the small heat shock protein alphaB-crystallin in eutopic endometrial epithelium from 38 women with peritoneal endometriosis diagnosed during investigation for secondary infertility. Spontaneous pregnancies within 1 year after medical and surgical treatment for endometriosis were recorded and semi-quantitative immunohistochemistry data compared between women with endometriosis who did or did not become pregnant and healthy controls. Stronger immunostaining for ER-alpha was detected in luminal and glandular endometrial epithelium from women with endometriosis who did not become pregnant during the post-treatment observation period versus endometriosis patients who became pregnant and controls. Staining levels of PR and PR-B were lower in patients without subsequent pregnancies than in the two other groups. Endometrial levels of alphaB-crystallin in endometriosis patients similar to those in controls were strongly correlated with the chance of becoming pregnant, whereas higher or lower levels were not. Mesh Terms: Adult| Biomarkers/metabolism| Biopsy| Endometriosis/*metabolism/pathology/physiopathology/therapy| Endometrium/*metabolism/pathology| Estrogen Receptor alpha/*metabolism| Estrogen Receptor beta/metabolism| Female| Fertility| Follow-Up Studies| H |
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